Mocking a dependent property with Moq

If I have a class that has a dependency that is resolved via property injection, is it possible to Mock the behavior of that property using Moq?

e.g.

    public class SomeClass
     {
        //empty constructor
        public SomeClass() {}

        //dependency
        public IUsefuleService Service {get;set;}

        public bool IsThisPossible(Object someObject)
        {
           //do some stuff

           //I want to mock Service and the result of GetSomethingGood
           var result = Service.GetSomethingGood(someObject);
        }

     }

So, SomeClass is under test and I am trying to figure out if I can mock the behavior of IUsefulService with Moq so when I test IsThisPossible and the line using the service is hit, the mock is used...